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pentobarbital will lower the extent or impact of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Impact of coadministering a robust CYP3A4 inducer with fedratinib hasn't been researched.pentobarbital will decrease the extent or impact of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metab